Non-pharmacological, multicomponent group therapy in patients with degenerative dementia: a 12-month randomzied, controlled trial
Identifieur interne : 000295 ( Main/Exploration ); précédent : 000294; suivant : 000296Non-pharmacological, multicomponent group therapy in patients with degenerative dementia: a 12-month randomzied, controlled trial
Auteurs : Elmar Graessel [Allemagne] ; Renate Stemmer [Allemagne] ; Birgit Eichenseer [Allemagne] ; Sabine Pickel [Allemagne] ; Carolin Donath [Allemagne] ; Johannes Kornhuber [Allemagne] ; Katharina Luttenberger [Allemagne]Source :
- BMC Medicine [ 1741-7015 ] ; 2011.
Abstract
Currently available pharmacological and non-pharmacological treatments have shown only modest effects in slowing the progression of dementia. Our objective was to assess the impact of a long-term non-pharmacological group intervention on cognitive function in dementia patients and on their ability to carry out activities of daily living compared to a control group receiving the usual care.
A randomized, controlled, single-blind longitudinal trial was conducted with 98 patients (follow-up: n = 61) with primary degenerative dementia in five nursing homes in Bavaria, Germany. The highly standardized intervention consisted of motor stimulation, practice in activities of daily living, and cognitive stimulation (acronym MAKS). It was conducted in groups of ten patients led by two therapists for 2 hours, 6 days a week for 12 months. Control patients received treatment as usual. Cognitive function was assessed using the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog), and the ability to carry out activities of daily living using the Erlangen Test of Activities of Daily Living (E-ADL test) at baseline and after 12 months.
Of the 553 individuals screened, 119 (21.5%) were eligible and 98 (17.7%) were ultimately included in the study. At 12 months, the results of the per protocol analysis (n = 61) showed that cognitive function and the ability to carry out activities of daily living had remained stable in the intervention group but had decreased in the control patients (ADAS-Cog: adjusted mean difference: -7.7, 95% CI -14.0 to -1.4,
A highly standardized, non-pharmacological, multicomponent group intervention conducted in a nursing-home setting was able to postpone a decline in cognitive function in dementia patients and in their ability to carry out activities of daily living for at least 12 months.
Url:
DOI: 10.1186/1741-7015-9-129
PubMed: 22133165
PubMed Central: 3254071
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000127
- to stream Pmc, to step Curation: 000126
- to stream Pmc, to step Checkpoint: 000110
- to stream Ncbi, to step Merge: 000058
- to stream Ncbi, to step Curation: 000058
- to stream Ncbi, to step Checkpoint: 000058
- to stream Main, to step Merge: 000295
- to stream Main, to step Curation: 000295
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Non-pharmacological, multicomponent group therapy in patients with degenerative dementia: a 12-month randomzied, controlled trial</title><author><name sortKey="Graessel, Elmar" sort="Graessel, Elmar" uniqKey="Graessel E" first="Elmar" last="Graessel">Elmar Graessel</name><affiliation wicri:level="1"><nlm:aff id="I1">Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Stemmer, Renate" sort="Stemmer, Renate" uniqKey="Stemmer R" first="Renate" last="Stemmer">Renate Stemmer</name><affiliation wicri:level="3"><nlm:aff id="I2">Catholic University of Applied Sciences Mainz, Department of Health and Nursing, Saarstrasse 3, 55122 Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Catholic University of Applied Sciences Mainz, Department of Health and Nursing, Saarstrasse 3, 55122 Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Eichenseer, Birgit" sort="Eichenseer, Birgit" uniqKey="Eichenseer B" first="Birgit" last="Eichenseer">Birgit Eichenseer</name><affiliation wicri:level="1"><nlm:aff id="I1">Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Pickel, Sabine" sort="Pickel, Sabine" uniqKey="Pickel S" first="Sabine" last="Pickel">Sabine Pickel</name><affiliation wicri:level="1"><nlm:aff id="I1">Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Donath, Carolin" sort="Donath, Carolin" uniqKey="Donath C" first="Carolin" last="Donath">Carolin Donath</name><affiliation wicri:level="1"><nlm:aff id="I1">Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Kornhuber, Johannes" sort="Kornhuber, Johannes" uniqKey="Kornhuber J" first="Johannes" last="Kornhuber">Johannes Kornhuber</name><affiliation wicri:level="1"><nlm:aff id="I1">Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Luttenberger, Katharina" sort="Luttenberger, Katharina" uniqKey="Luttenberger K" first="Katharina" last="Luttenberger">Katharina Luttenberger</name><affiliation wicri:level="1"><nlm:aff id="I1">Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22133165</idno><idno type="pmc">3254071</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254071</idno><idno type="RBID">PMC:3254071</idno><idno type="doi">10.1186/1741-7015-9-129</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000127</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000127</idno><idno type="wicri:Area/Pmc/Curation">000126</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000126</idno><idno type="wicri:Area/Pmc/Checkpoint">000110</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000110</idno><idno type="wicri:Area/Ncbi/Merge">000058</idno><idno type="wicri:Area/Ncbi/Curation">000058</idno><idno type="wicri:Area/Ncbi/Checkpoint">000058</idno><idno type="wicri:Area/Main/Merge">000295</idno><idno type="wicri:Area/Main/Curation">000295</idno><idno type="wicri:Area/Main/Exploration">000295</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Non-pharmacological, multicomponent group therapy in patients with degenerative dementia: a 12-month randomzied, controlled trial</title><author><name sortKey="Graessel, Elmar" sort="Graessel, Elmar" uniqKey="Graessel E" first="Elmar" last="Graessel">Elmar Graessel</name><affiliation wicri:level="1"><nlm:aff id="I1">Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Stemmer, Renate" sort="Stemmer, Renate" uniqKey="Stemmer R" first="Renate" last="Stemmer">Renate Stemmer</name><affiliation wicri:level="3"><nlm:aff id="I2">Catholic University of Applied Sciences Mainz, Department of Health and Nursing, Saarstrasse 3, 55122 Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Catholic University of Applied Sciences Mainz, Department of Health and Nursing, Saarstrasse 3, 55122 Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Eichenseer, Birgit" sort="Eichenseer, Birgit" uniqKey="Eichenseer B" first="Birgit" last="Eichenseer">Birgit Eichenseer</name><affiliation wicri:level="1"><nlm:aff id="I1">Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Pickel, Sabine" sort="Pickel, Sabine" uniqKey="Pickel S" first="Sabine" last="Pickel">Sabine Pickel</name><affiliation wicri:level="1"><nlm:aff id="I1">Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Donath, Carolin" sort="Donath, Carolin" uniqKey="Donath C" first="Carolin" last="Donath">Carolin Donath</name><affiliation wicri:level="1"><nlm:aff id="I1">Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Kornhuber, Johannes" sort="Kornhuber, Johannes" uniqKey="Kornhuber J" first="Johannes" last="Kornhuber">Johannes Kornhuber</name><affiliation wicri:level="1"><nlm:aff id="I1">Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Luttenberger, Katharina" sort="Luttenberger, Katharina" uniqKey="Luttenberger K" first="Katharina" last="Luttenberger">Katharina Luttenberger</name><affiliation wicri:level="1"><nlm:aff id="I1">Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Friedrich-Alexander-Universität Erlangen-Nürnberg, Clinic for Psychiatry and Psychotherapy, Department of Medical Psychology and Medical Sociology, Schwabachanlage 6, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author></analytic><series><title level="j">BMC Medicine</title><idno type="eISSN">1741-7015</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Currently available pharmacological and non-pharmacological treatments have shown only modest effects in slowing the progression of dementia. Our objective was to assess the impact of a long-term non-pharmacological group intervention on cognitive function in dementia patients and on their ability to carry out activities of daily living compared to a control group receiving the usual care.</p></sec><sec><title>Methods</title><p>A randomized, controlled, single-blind longitudinal trial was conducted with 98 patients (follow-up: n = 61) with primary degenerative dementia in five nursing homes in Bavaria, Germany. The highly standardized intervention consisted of motor stimulation, practice in activities of daily living, and cognitive stimulation (acronym MAKS). It was conducted in groups of ten patients led by two therapists for 2 hours, 6 days a week for 12 months. Control patients received treatment as usual. Cognitive function was assessed using the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog), and the ability to carry out activities of daily living using the Erlangen Test of Activities of Daily Living (E-ADL test) at baseline and after 12 months.</p></sec><sec><title>Results</title><p>Of the 553 individuals screened, 119 (21.5%) were eligible and 98 (17.7%) were ultimately included in the study. At 12 months, the results of the per protocol analysis (n = 61) showed that cognitive function and the ability to carry out activities of daily living had remained stable in the intervention group but had decreased in the control patients (ADAS-Cog: adjusted mean difference: -7.7, 95% CI -14.0 to -1.4, <italic>P </italic>= 0.018, Cohen's d = 0.45; E-ADL test: adjusted mean difference: 3.6, 95% CI 0.7 to 6.4, <italic>P </italic>= 0.015, Cohen's d = 0.50). The effect sizes for the intervention were greater in the subgroup of patients (n = 50) with mild to moderate disease (ADAS-Cog: Cohen's d = 0.67; E-ADL test: Cohen's d = 0.69).</p></sec><sec><title>Conclusions</title><p>A highly standardized, non-pharmacological, multicomponent group intervention conducted in a nursing-home setting was able to postpone a decline in cognitive function in dementia patients and in their ability to carry out activities of daily living for at least 12 months.</p></sec><sec><title>Trial Registration</title><p><ext-link ext-link-type="uri" xlink:href="http://www.isrctn.com">http://www.isrctn.com</ext-link> Identifier: <ext-link ext-link-type="uri" xlink:href="http://www.controlled-trials.com/ISRCTN87391496">ISRCTN87391496</ext-link></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Trinh, Nh" uniqKey="Trinh N">NH Trinh</name></author><author><name sortKey="Hoblyn, J" uniqKey="Hoblyn J">J Hoblyn</name></author><author><name sortKey="Mohanty, S" uniqKey="Mohanty S">S Mohanty</name></author><author><name sortKey="Yaffe, K" uniqKey="Yaffe K">K Yaffe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loy, C" uniqKey="Loy C">C Loy</name></author><author><name sortKey="Schneider, L" uniqKey="Schneider L">L Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Birks, J" uniqKey="Birks J">J Birks</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Teri, L" uniqKey="Teri L">L Teri</name></author><author><name sortKey="Gibbons, Le" uniqKey="Gibbons L">LE Gibbons</name></author><author><name sortKey="Mccurry, Sm" uniqKey="Mccurry S">SM McCurry</name></author><author><name sortKey="Logsdon, Rg" uniqKey="Logsdon R">RG Logsdon</name></author><author><name sortKey="Buchner, Dm" uniqKey="Buchner D">DM Buchner</name></author><author><name sortKey="Barlow, We" uniqKey="Barlow W">WE Barlow</name></author><author><name sortKey="Kukull, Wa" uniqKey="Kukull W">WA Kukull</name></author><author><name sortKey="Lacroix, Az" uniqKey="Lacroix A">AZ LaCroix</name></author><author><name sortKey="Mccormick, W" uniqKey="Mccormick W">W McCormick</name></author><author><name sortKey="Larson, Eb" uniqKey="Larson E">EB Larson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gitlin, Ln" uniqKey="Gitlin L">LN Gitlin</name></author><author><name sortKey="Winter, L" uniqKey="Winter L">L Winter</name></author><author><name sortKey="Dennis, Mp" uniqKey="Dennis M">MP Dennis</name></author><author><name sortKey="Hodgson, N" uniqKey="Hodgson N">N Hodgson</name></author><author><name sortKey="Hauck, Ww" uniqKey="Hauck W">WW Hauck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luijpen, Mw" uniqKey="Luijpen M">MW Luijpen</name></author><author><name sortKey="Scherder, E" uniqKey="Scherder E">E Scherder</name></author><author><name sortKey="Van Someren, Ej" uniqKey="Van Someren E">EJ Van Someren</name></author><author><name sortKey="Swaab, D" uniqKey="Swaab D">D Swaab</name></author><author><name sortKey="Sergeant, Ja" uniqKey="Sergeant J">JA Sergeant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coelho, Fg" uniqKey="Coelho F">FG Coelho</name></author><author><name sortKey="Santos Galduroz, Rf" uniqKey="Santos Galduroz R">RF Santos-Galduroz</name></author><author><name sortKey="Gobbi, S" uniqKey="Gobbi S">S Gobbi</name></author><author><name sortKey="Stella, F" uniqKey="Stella F">F Stella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altman, D" uniqKey="Altman D">D Altman</name></author><author><name sortKey="Schulz, K" uniqKey="Schulz K">K Schulz</name></author><author><name sortKey="Moher, D" uniqKey="Moher D">D Moher</name></author><author><name sortKey="Egger, M" uniqKey="Egger M">M Egger</name></author><author><name sortKey="Davidoff, F" uniqKey="Davidoff F">F Davidoff</name></author><author><name sortKey="Elbourne, D" uniqKey="Elbourne D">D Elbourne</name></author><author><name sortKey="Gotzsche, P" uniqKey="Gotzsche P">P Gotzsche</name></author><author><name sortKey="Lang, T" uniqKey="Lang T">T Lang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clare, L" uniqKey="Clare L">L Clare</name></author><author><name sortKey="Woods, R" uniqKey="Woods R">R Woods</name></author><author><name sortKey="Moniz Cook, E" uniqKey="Moniz Cook E">E Moniz-Cook</name></author><author><name sortKey="Orrell, M" uniqKey="Orrell M">M Orrell</name></author><author><name sortKey="Spector, A" uniqKey="Spector A">A Spector</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vink, Ac" uniqKey="Vink A">AC Vink</name></author><author><name sortKey="Birks, J" uniqKey="Birks J">J Birks</name></author><author><name sortKey="Bruinsma, Ms" uniqKey="Bruinsma M">MS Bruinsma</name></author><author><name sortKey="Scholten, Rjpm" uniqKey="Scholten R">RJPM Scholten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woods, B" uniqKey="Woods B">B Woods</name></author><author><name sortKey="Spector, Ae" uniqKey="Spector A">AE Spector</name></author><author><name sortKey="Jones, Ca" uniqKey="Jones C">CA Jones</name></author><author><name sortKey="Orrell, M" uniqKey="Orrell M">M Orrell</name></author><author><name sortKey="Davies, Sp" uniqKey="Davies S">SP Davies</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holt, Fe" uniqKey="Holt F">FE Holt</name></author><author><name sortKey="Birks, Tph" uniqKey="Birks T">TPH Birks</name></author><author><name sortKey="Thorgrimsen, Lm" uniqKey="Thorgrimsen L">LM Thorgrimsen</name></author><author><name sortKey="Spector, Ae" uniqKey="Spector A">AE Spector</name></author><author><name sortKey="Wiles, A" uniqKey="Wiles A">A Wiles</name></author><author><name sortKey="Orrell, M" uniqKey="Orrell M">M Orrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hansen, Vn" uniqKey="Hansen V">VN Hansen</name></author><author><name sortKey="J Rgensen, T" uniqKey="J Rgensen T">T Jørgensen</name></author><author><name sortKey=" Rtenblad, L" uniqKey=" Rtenblad L">L Ørtenblad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buschert, Vc" uniqKey="Buschert V">VC Buschert</name></author><author><name sortKey="Friese, U" uniqKey="Friese U">U Friese</name></author><author><name sortKey="Teipel, Sj" uniqKey="Teipel S">SJ Teipel</name></author><author><name sortKey="Schneider, P" uniqKey="Schneider P">P Schneider</name></author><author><name sortKey="Merensky, W" uniqKey="Merensky W">W Merensky</name></author><author><name sortKey="Rujescu, D" uniqKey="Rujescu D">D Rujescu</name></author><author><name sortKey="Moller, Hj" uniqKey="Moller H">HJ Moller</name></author><author><name sortKey="Hampel, H" uniqKey="Hampel H">H Hampel</name></author><author><name sortKey="Buerger, K" uniqKey="Buerger K">K Buerger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spector, A" uniqKey="Spector A">A Spector</name></author><author><name sortKey="Orrell, M" uniqKey="Orrell M">M Orrell</name></author><author><name sortKey="Woods, B" uniqKey="Woods B">B Woods</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gr El, E" uniqKey="Gr El E">E Gräßel</name></author><author><name sortKey="Wiltfang, J" uniqKey="Wiltfang J">J Wiltfang</name></author><author><name sortKey="Kornhuber, J" uniqKey="Kornhuber J">J Kornhuber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olazaran, J" uniqKey="Olazaran J">J Olazarán</name></author><author><name sortKey="Reisberg, B" uniqKey="Reisberg B">B Reisberg</name></author><author><name sortKey="Clare, L" uniqKey="Clare L">L Clare</name></author><author><name sortKey="Cruz, I" uniqKey="Cruz I">I Cruz</name></author><author><name sortKey="Pe A Casanova, J" uniqKey="Pe A Casanova J">J Peña-Casanova</name></author><author><name sortKey="Del Ser, T" uniqKey="Del Ser T">T Del Ser</name></author><author><name sortKey="Woods, B" uniqKey="Woods B">B Woods</name></author><author><name sortKey="Beck, C" uniqKey="Beck C">C Beck</name></author><author><name sortKey="Auer, S" uniqKey="Auer S">S Auer</name></author><author><name sortKey="Lai, C" uniqKey="Lai C">C Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olazaran, J" uniqKey="Olazaran J">J Olazarán</name></author><author><name sortKey="Mu Iz, R" uniqKey="Mu Iz R">R Muñiz</name></author><author><name sortKey="Reisberg, B" uniqKey="Reisberg B">B Reisberg</name></author><author><name sortKey="Pe A Casanova, J" uniqKey="Pe A Casanova J">J Peña-Casanova</name></author><author><name sortKey="Del Ser, T" uniqKey="Del Ser T">T del Ser</name></author><author><name sortKey="Cruz Jentoft, Aj" uniqKey="Cruz Jentoft A">AJ Cruz-Jentoft</name></author><author><name sortKey="Serrano, P" uniqKey="Serrano P">P Serrano</name></author><author><name sortKey="Navarro, E" uniqKey="Navarro E">E Navarro</name></author><author><name sortKey="Garcia De La Rocha, Ml" uniqKey="Garcia De La Rocha M">ML García de la Rocha</name></author><author><name sortKey="Frank, A" uniqKey="Frank A">A Frank</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tadaka, E" uniqKey="Tadaka E">E Tadaka</name></author><author><name sortKey="Kanagawa, K" uniqKey="Kanagawa K">K Kanagawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heyn, P" uniqKey="Heyn P">P Heyn</name></author><author><name sortKey="Abreu, B" uniqKey="Abreu B">B Abreu</name></author><author><name sortKey="Ottenbacher, K" uniqKey="Ottenbacher K">K Ottenbacher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teri, L" uniqKey="Teri L">L Teri</name></author><author><name sortKey="Logsdon, Rg" uniqKey="Logsdon R">RG Logsdon</name></author><author><name sortKey="Mccurry, Sm" uniqKey="Mccurry S">SM McCurry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Helbostad, Jl" uniqKey="Helbostad J">JL Helbostad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sitzer, D" uniqKey="Sitzer D">D Sitzer</name></author><author><name sortKey="Twamley, E" uniqKey="Twamley E">E Twamley</name></author><author><name sortKey="Jeste, D" uniqKey="Jeste D">D Jeste</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, F" uniqKey="Yu F">F Yu</name></author><author><name sortKey="Rose, Km" uniqKey="Rose K">KM Rose</name></author><author><name sortKey="Burgener, Sc" uniqKey="Burgener S">SC Burgener</name></author><author><name sortKey="Cunningham, C" uniqKey="Cunningham C">C Cunningham</name></author><author><name sortKey="Buettner, Ll" uniqKey="Buettner L">LL Buettner</name></author><author><name sortKey="Beattie, E" uniqKey="Beattie E">E Beattie</name></author><author><name sortKey="Bossen, Al" uniqKey="Bossen A">AL Bossen</name></author><author><name sortKey="Buckwalter, Kc" uniqKey="Buckwalter K">KC Buckwalter</name></author><author><name sortKey="Fick, Dm" uniqKey="Fick D">DM Fick</name></author><author><name sortKey="Fitzsimmons, S" uniqKey="Fitzsimmons S">S Fitzsimmons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Acevedo, A" uniqKey="Acevedo A">A Acevedo</name></author><author><name sortKey="Loewenstein, Da" uniqKey="Loewenstein D">DA Loewenstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Esther, M" uniqKey="Esther M">M Esther</name></author><author><name sortKey="Steultjens, J" uniqKey="Steultjens J">J Steultjens</name></author><author><name sortKey="Dekker, J" uniqKey="Dekker J">J Dekker</name></author><author><name sortKey="Bouter, L" uniqKey="Bouter L">L Bouter</name></author><author><name sortKey="Jellema, S" uniqKey="Jellema S">S Jellema</name></author><author><name sortKey="Bakker, E" uniqKey="Bakker E">E Bakker</name></author><author><name sortKey="Van Den Ende, C" uniqKey="Van Den Ende C">C van den Ende</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steultjens, Em" uniqKey="Steultjens E">EM Steultjens</name></author><author><name sortKey="Dekker, J" uniqKey="Dekker J">J Dekker</name></author><author><name sortKey="Bouter, Lm" uniqKey="Bouter L">LM Bouter</name></author><author><name sortKey="Leemrijse, Cj" uniqKey="Leemrijse C">CJ Leemrijse</name></author><author><name sortKey="Van Den Ende, Ch" uniqKey="Van Den Ende C">CH van den Ende</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, A W" uniqKey="Chan A">A-W Chan</name></author><author><name sortKey="Altman, D" uniqKey="Altman D">D Altman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pickel, S" uniqKey="Pickel S">S Pickel</name></author><author><name sortKey="Graessel, E" uniqKey="Graessel E">E Graessel</name></author><author><name sortKey="Luttenberger, K" uniqKey="Luttenberger K">K Luttenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Folstein, M" uniqKey="Folstein M">M Folstein</name></author><author><name sortKey="Folstein, S" uniqKey="Folstein S">S Folstein</name></author><author><name sortKey="Mchugh, P" uniqKey="Mchugh P">P McHugh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ihl, R" uniqKey="Ihl R">R Ihl</name></author><author><name sortKey="Weiher, G" uniqKey="Weiher G">G Weiher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graessel, E" uniqKey="Graessel E">E Graessel</name></author><author><name sortKey="Viegas, R" uniqKey="Viegas R">R Viegas</name></author><author><name sortKey="Stemmer, R" uniqKey="Stemmer R">R Stemmer</name></author><author><name sortKey="Kuchly, B" uniqKey="Kuchly B">B Küchly</name></author><author><name sortKey="Kornhuber, J" uniqKey="Kornhuber J">J Kornhuber</name></author><author><name sortKey="Donath, C" uniqKey="Donath C">C Donath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charlson, M" uniqKey="Charlson M">M Charlson</name></author><author><name sortKey="Pompei, P" uniqKey="Pompei P">P Pompei</name></author><author><name sortKey="Ales, K" uniqKey="Ales K">K Ales</name></author><author><name sortKey="Mackenzie, C" uniqKey="Mackenzie C">C MacKenzie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hedges, Lv" uniqKey="Hedges L">LV Hedges</name></author><author><name sortKey="Olkin, I" uniqKey="Olkin I">I Olkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altman, D" uniqKey="Altman D">D Altman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Onor, M" uniqKey="Onor M">M Onor</name></author><author><name sortKey="Trevisiol, M" uniqKey="Trevisiol M">M Trevisiol</name></author><author><name sortKey="Negro, C" uniqKey="Negro C">C Negro</name></author><author><name sortKey="Alessandra, S" uniqKey="Alessandra S">S Alessandra</name></author><author><name sortKey="Saina, M" uniqKey="Saina M">M Saina</name></author><author><name sortKey="Aguglia, E" uniqKey="Aguglia E">E Aguglia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gitlin, L" uniqKey="Gitlin L">L Gitlin</name></author><author><name sortKey="Winter, L" uniqKey="Winter L">L Winter</name></author><author><name sortKey="Dennis, Mp" uniqKey="Dennis M">MP Dennis</name></author><author><name sortKey="Hodgson, N" uniqKey="Hodgson N">N Hodgson</name></author><author><name sortKey="Hauck, Ww" uniqKey="Hauck W">WW Hauck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neal, M" uniqKey="Neal M">M Neal</name></author><author><name sortKey="Barton Wright, P" uniqKey="Barton Wright P">P Barton Wright</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eichenseer, B" uniqKey="Eichenseer B">B Eichenseer</name></author><author><name sortKey="Graessel, E" uniqKey="Graessel E">E Graessel</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Moyenne-Franconie</li><li>Rhénanie-Palatinat</li></region><settlement><li>Erlangen</li><li>Mayence</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Graessel, Elmar" sort="Graessel, Elmar" uniqKey="Graessel E" first="Elmar" last="Graessel">Elmar Graessel</name></region><name sortKey="Donath, Carolin" sort="Donath, Carolin" uniqKey="Donath C" first="Carolin" last="Donath">Carolin Donath</name><name sortKey="Eichenseer, Birgit" sort="Eichenseer, Birgit" uniqKey="Eichenseer B" first="Birgit" last="Eichenseer">Birgit Eichenseer</name><name sortKey="Kornhuber, Johannes" sort="Kornhuber, Johannes" uniqKey="Kornhuber J" first="Johannes" last="Kornhuber">Johannes Kornhuber</name><name sortKey="Luttenberger, Katharina" sort="Luttenberger, Katharina" uniqKey="Luttenberger K" first="Katharina" last="Luttenberger">Katharina Luttenberger</name><name sortKey="Pickel, Sabine" sort="Pickel, Sabine" uniqKey="Pickel S" first="Sabine" last="Pickel">Sabine Pickel</name><name sortKey="Stemmer, Renate" sort="Stemmer, Renate" uniqKey="Stemmer R" first="Renate" last="Stemmer">Renate Stemmer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sarre/explor/MusicSarreV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000295 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000295 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sarre
|area= MusicSarreV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3254071
|texte= Non-pharmacological, multicomponent group therapy in patients with degenerative dementia: a 12-month randomzied, controlled trial
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22133165" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MusicSarreV3
| This area was generated with Dilib version V0.6.33. |  |